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It was a good assumption. These days most games will work flawlessly in WINE/Proton, but the same can’t be said for other Windows software, sadly.

The Affinity suite is notoriously difficult to get working properly in WINE and/or Proton

I currently run it in a Windows 10 VM using virt-manager and the virtio drivers from RedHat to enable OpenGL acceleration on a Windows guest. It is a decent experience. Would probably be much better if I passed a USB pointer directly into the VM instead of relying on virtualization.

Haven’t tried it in WINE, and probably will never bother until the Affinity team take it seriously.

Can’t speak to your other software, but battle.net and diablo 2 run great on Linux via WINE/Proton

And everyone else’s that uses Fedora?

It looks like the 5800x3D (and other AM4 cups) have been discontinued. They are going out of stock everywhere. Might be better to go with AM5 (7000 and 9000 series) at this point.

How are you launching the exe with WINE? Try doing it via the command line if you aren’t already. That way you may get some more information about why it isn’t working. Its as simple as wine path/to/your/exe

You could also try something like Bottles, which will let you use possibly newer versions of WINE without modifying your system’s WINE.