ooooh this is it! If you wanted to optimize evil add photosynthesis and nitrogen fixing and you’ve got it.

Hell, I’d bet you could work on the chloroplasts in isolation of the rest of the organism to parallel path the research and optimize.

I’ve been out of synthetic bio for damn near two decades now, and an undergrad when was I even in it, but I’m not so sure. PCR didn’t come around until 85. I had professors that used to do every cycle manually. Human genome project wrapped in 03(?). You can order custom oligos for like $0.13USD a base pair mail order now. You type it in on a webform, a machine creates a custom molecule for you, and if you want to pay a little extra you can have it over-night. I suppose it depends what you call “near future”, and synthetic biology has always had moving goal posts when it came to “functional liposome” and “synthetic life”, but I don’t know… shit can move fast sometimes.

you bet! I just remember that because we were learning about glucose is taken up (it’s an active process swapping sodium and potassium). Another fun bonus for you: thats what they figured out at university of florida (or at least implemented). Someone had the bright idea that if you gave athletes a beverage with not only glucose but the specific K+/Na+ they needed to run the enzymes that took up the glucose, they might perform better.

So the football team, the Gators, got a special concoction of “Gator-aide” at their games. It smelled kinda like sweat, wasn’t sweet (glucose isn’t actually that sweet), so the formula was eventually tweaked, the branding changed to “gatorade”, but the university still RAKES in the money for that license.

edit: Just to add another cool layer. The money to date has nothing to do with the innovation, that patent would have expired (which is fantastic because that concoction is basically how you treat all sorts of things like cholera where the body dies of dehydration despite having clean water, the UN, FEMA, etc basically hands out off-brand gatorade mix). The reason U of florida still gets the money isn’t formula, it’s the brand. Pepsi pays them for that “gator-aide” name. It’s rare IP perfect win; hydration mix for all, and if you there’s a business to be made selling it under a specific name so be it, doesn’t matter much to the person whos life is saved because of “generic hydration mix”.

Ok. THANK YOU. I also have to say my biggest issue with the newer one (I forget which) is when the parks going to hell, and the park director just decides to go off into the jungle. Like outside of just design of the park, there is NO way you don’t have rigid protocols in-place. Like you read about half the crap Disney does/can do at their parks… there’s no way the head of the park just goes “oh you guys got this, I’ll be back at some point, just do your best”.

Like if ONLY for the reason it would be a known PR disaster for something that in universe already had PR disasters… that shit would have been drilled in since day -1000. It’s my biggest issue with the writing because it’s not even sci-fi.

/end rant.

Sorry about your grandfather. There’s probably more than one mechanism for alzeimers (not an expert), but amaloyid plaque formation, which is definitely A way to develop alzheimer’s, is indeed a prion like event. I’m not sure if “prion” has some hyper-precise definition but the ideas similar: you get one amalyoid protein that misfolds, and acts as a nucleation site misfolding and agglomerating others.

“mirror sugar”. Just dropping some trivia. The first “no calorie” sweetners were actually mirror sugar. They’d activate tastebuds but couldn’t be adsorbed in the gut. Only problem was people crapped their brains out because the osmotic balance went to hell.

edit: I think technically the first zero calorie sugar would have been literal lead (as in Pb) back in the ancient roman days, but I’m not really counting that.

Jumping in down here. I agree with you entirely that racemic mixes are a very different ball than mirror organisms; it’s been a known thing for a long time, and while I’m not positive, I’d be very surprised if FDA testing didn’t include different chiralities of both the original compound and metabolite.

That being said, there’s nothing to say one version of a chiral protein can’t behave like a prion. I don’t know of any evidence where we’ve seen it happen either, though. There’s also potentially the issue of partial bonding. Not every domain on every protein is chiral. If a mirror protein has some domains that bind but other functional domains that are incompatible, you could see it incorporated into complex that either 1) are now non-functional or 2) have alternate folding that behaves similar to prions.

Again though, I can’t point to any evidence of that. You can do the arrow pushing that shows how you get tetrodoxin from the stuff in your tea or coffee, it doesn’t mean it’s actually going to happen beyond the statistical realm interesting only to quantum physicists.

Just chiming in because your comments are level headed and you’ve clearly got some knowledge in the area and appreciate the discussion. Looking forward to digging into the report this weekend, I had no idea this was even something are even attempting!

Yeah agree. They’re kind of sold as a cure all, which they’re not, but if you have a very specific problem they’ll help. I think the thing is a lot of times people use them without addressing the root cause. But it’s definitely saved me a deep clean before.

OK, I’m going to save you time because I do some controls and totally get how “easy” demand management should be given how simple most devices are.

But WHAT?! Thats all built into the grid over there??? That’s AWESOME. Let me see if I have this right: there’s essentially a small transient frequency modulation in the 60hz(?) in the grid that allows devices to receive a “off” signal?

I could be wrong but I’m 90% sure we’ve got nothing like that in the states. MAYBE there’s something like that for communicating with the meter itself but certainly not past the meter.

… Consumer water heaters in Germany are built in as demand shaving??? That is so damn cool.