Absolutely, though if you have to run it twice anyway you don’t have to cram it full on the first go no matter what. But I’ve seen some truly horrific stuff, plates and bowls just stacked on top of each other, no way for the water to get in all the crevices
Not to worry for you see, the ‘single slice of pizza’ you mention is actually a Mega Slice, which is probably at least 3 times bigger than a regular slice.